Chemokine-cytokine fusion proteins of SDF-1 and CD40L
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United States of America Patent
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Jul 2, 2019
Grant Date -
Nov 16, 2017
app pub date -
Jul 25, 2017
filing date -
Dec 5, 2012
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Abstract
The present invention provides a fusion protein, comprising a chemokine polypeptide, which is a chemokine or a receptor binding domain thereof; and a cytokine polypeptide connected to said chemokine polypeptide, which is an interleukin, a TNF-superfamily cytokine or a receptor-binding domain thereof; wherein the chemokine polypeptide and the cytokine polypeptide have a common target cell, and the fusion protein has an improved chemokine activity as compared to the chemokine polypeptide, and an improved cytokine activity as compared to the cytokine polypeptide.
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