DEUTERATED HETEROARYL SULFONAMIDES AND THEIR USE
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United States of America Patent
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May 16, 2017
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May 16, 2016
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Abstract
Compunds are provided that act as potent antagonists of the CCR2 receptor. These compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives that include deuterium modifications and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.
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