Antibody-drug conjugates of tubulysin analogs with enhanced stability

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United States of America Patent

PATENT NO 10279049
APP PUB NO 20170326247A1
SERIAL NO

15587927

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Abstract

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The drug component of an antibody-drug conjugate having a structure according to formula (II), where Ab, m, n, R1, R2, R3, R4, and R5 are as defined in the application, exhibits unexpectedly improved stability.

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BRISTOL-MYERS SQUIBB COMPANYROUTE 206 & PROVINCE LINE ROAD PRINCETON NJ 08543

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cong, Qiang Palo Alto, US 18 221
Gangwar, Sanjeev Foster City, US 93 1800
Rangan, Vangipuram S Pleasant Hill, US 6 4
Sung, Mei-Chen Milpitas, US 1 1

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