Method and system for determining the influence of experimental parameters on a liquid chromatography protocol

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United States of America Patent

PATENT NO 11460455
APP PUB NO 20170322190A1
SERIAL NO

15525613

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Abstract

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Method for determining the influence of least a first and a second experimental parameter on a liquid chromatography protocol for purifying one or more target molecules from a sample, comprising the steps: —performing chromatography purifications of the sample at a plurality of different experimental conditions where at least the first and the second experimental parameter each are varied over a predetermined range, each purification being registered as a chromatogram by monitoring an output parameter indicative of the purification result during the purification; and—displaying in a graphical user interface at least a subset of the registered chromatograms as chromatogram-miniatures in an evaluation diagram wherein the position of each displayed chromatogram-miniature is determined by the experimental parameters for the corresponding purification, thereby allowing a user to visually determine trends and the influence of the experimental parameters on the liquid chromatography protocol.

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Patent Owner(s)

Patent OwnerAddress
CYTIVA SWEDEN ABBJORKGATAN 30 UPPSALA 751 84

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Arthursson, Johan Uppsala, SE 6 6
Nyholm, Lena Uppsala, SE 3 4
Ohman, Ulrika Uppsala, SE 2 11
Olsson, Eva Uppsala, SE 2 63

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