Inhibition of nonsense mediated mRNA decay by drugs that prevent hypusination of eukaryotic initiation factor 5A

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United States of America Patent

PATENT NO 9849146
SERIAL NO

14126342

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Abstract

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Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD an inhibitor of NMD and a nonsense suppressor, whereby degradation of NMD susceptible mRNA is decreased and translation termination at a misplaced nonsense codon is blocked.

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Patent Owner(s)

Patent OwnerAddress
RUTGERS THE STATE UNIVERSITY OF NEW JERSEY83 SOMERSET STREET NEW BRUNSWICK NJ 08901

International Classification(s)

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  • 2012 Application Filing Year
  • A61K Class
  • 11964 Applications Filed
  • 9694 Patents Issued To-Date
  • 81.03 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances201220132014201520162017201820192020202120222023202420250255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hanauske-Abel, Hartmut M Edgewater, US 17 76
Hoque, Mainul North Arlington, US 6 22
Mathews, Michael B Montclair, US 36 2028
Pe'ery, Tsafi Montclair, US 5 25

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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges763281956782001332911183139501 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +050010001500200025003000350040004500500055006000650070007500800085009000

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