Inhibition of nonsense mediated mRNA decay by drugs that prevent hypusination of eukaryotic initiation factor 5A

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United States of America Patent

PATENT NO 9849146
SERIAL NO

14126342

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Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD an inhibitor of NMD and a nonsense suppressor, whereby degradation of NMD susceptible mRNA is decreased and translation termination at a misplaced nonsense codon is blocked.

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Patent Owner(s)

Patent OwnerAddress
RUTGERS THE STATE UNIVERSITY OF NEW JERSEY83 SOMERSET STREET NEW BRUNSWICK NJ 08901

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hanauske-Abel, Hartmut M Edgewater, US 17 76
Hoque, Mainul North Arlington, US 6 22
Mathews, Michael B Montclair, US 36 2028
Pe'ery, Tsafi Montclair, US 5 25

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