Twin-screw dry granulation for producing solid formulations
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United States of America Patent
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Sep 29, 2020
Grant Date -
Nov 9, 2017
app pub date -
Apr 21, 2017
filing date -
Apr 22, 2016
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Abstract
A dry granulation process using a twin-screw extruder for granulating a powder mixture which includes at least one active ingredient and at least one carrier. The process includes steps of kneading the powder mixture in the screw barrel of the twin-screw extruder at a barrel temperature below a melting point of the at least one active ingredient and a melting point or a glass transition temperature of the at least one carrier to provide a kneaded powder mixture, and extruding the kneaded powder mixture to form granules. Granules and tablets produced using the dry granulation process in the twin-screw extruder are also provided.
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