INGESTIBLE FORMULATIONS FOR TRANSIENT, NONINVASIVE REDUCTION OF GASTRIC VOLUME
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Jul 26, 2017
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Dec 19, 2002
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Provided are ingestible polymeric formulations for the reduction of gastric volume in the treatment of overweight patients, and methods of use thereof. One method involves ingesting one or more ingestible tablets comprising cross-linked polymers formed in a packed mass within the one or more ingestible tablets into a stomach of the subject, wherein the cross-linked polymers comprise a polymer hydrogel comprising carboxymethylcellulose and a carboxylic acid; disintegrating an acid-sensitive gelatin coating such that the coating disintegrates in the gastric fluid and the cross-linked polymers disperse in the stomach; and maintaining the reduction in gastric volume such that a sensation of fullness is induced in the subject without releasing a drug which induces the sensation.
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