Predicting genetically stable recombinant protein production in early cell line development
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United States of America Patent
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Feb 9, 2021
Grant Date -
Nov 2, 2017
app pub date -
Nov 12, 2015
filing date -
Nov 12, 2014
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Abstract
The present invention relates in general to the field of recombinant protein expression. In particular, the present invention relates to a method for selecting a suitable candidate cell clone for recombinant protein expression and to a host cell for recombinant protein expression, the host cell exhibiting artificially modified gene expression of at least one gene selected from the group consisting of: Hist1h2bc, Egrl, BX842664.2/Hist 1h3c, Dhfr, Fgfr2, AC115880.11, Mmp10, Vsnll (optional), CU459186.17, El 30203 B14Rik, Cspg4, C1qtnf1, Foxp2, and Ptpre.
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