NOVEL CHIMERIC ANTIGEN RECEPTORS

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United States of America Patent

SERIAL NO

15291226

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention relates to chimeric antigen receptor (CAR) scaffolds comprising: a target binding domain; a spacer region; a transmembrane domain; and an intracellular effector domain, wherein the spacer region comprises at least one, or multiples of, domains 2, 3 or 4 or a combination thereof of a CD4 molecule. The invention also relates to polynucleotides and expression vectors encoding said CAR scaffold and immunomodulatory cells comprising said CAR scaffold. The invention also relates to methods of engineering an immunomodulatory cell to comprise said CAR scaffold

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Patent Owner(s)

Patent OwnerAddress
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED980 GREAT WEST ROAD BRENTFORD MIDDLESEX TW8 9GS

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
BATUWANGALA, Thil Dinuk Stevenage, GB 8 49

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