Process for the conjugation of a peptide or protein with a reagent comprising a leaving group including a portion of PEG
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United States of America Patent
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Nov 17, 2020
Grant Date -
Oct 26, 2017
app pub date -
Oct 8, 2015
filing date -
Oct 14, 2014
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Abstract
The invention relates to novel conjugating reagents capable of reaction with at least one nucleophile present in a peptide or protein, which contain at least one leaving group which is lost on reaction with said nucleophile, in which the leaving group includes a portion —(CH2CH2O)n—, in which n is a number of six or more; and novel processes for the preparation of conjugates containing peptides or proteins made using such reagents.
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