POLARIZATION OF MACROPHAGES TO A HEALING PHENOTYPE BY CARDIOSPHERE-DERIVED CELLS AND BY THE EXOSOMES SECRETED BY SUCH CELLS
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Oct 6, 2015
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Oct 6, 2014
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Described herein are compositions and techniques related to generation and therapeutic application of stem cell-derived exosomes. The Inventors have discovered cardiosphere-derived cells (CDCs) and their secreted exosomes mediate such inflammatory processes, by, for example, shifting macrophages away from a proinflammatory M1 phenotype toward M2 healing phenotype. This suggests compositions and techniques for use in both long-term reversal of heart and vascular disease pathology, and protection against such disease progression via modulation of inflammation and immune responses.
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