Programmed cargo release using nucleic acid-stabilized micelles
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United States of America Patent
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Sep 22, 2020
Grant Date -
Oct 26, 2017
app pub date -
Oct 7, 2015
filing date -
Oct 9, 2014
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Abstract
Methods and compositions for serum-stabilizing micelles for drug delivery or imaging agent delivery are provided, as well as methods and compositions to enhance micelle-mediated drug delivery. This invention provides a process for synthesizing a lipid micelle comprising one or more lipid-oligonucleotide conjugate molecules, the process comprising contacting an amount of lipid molecules with an amount of lipid-oligonucleotide conjugate molecules sufficient to create a lipid micelle comprising lipid-oligonucleotide conjugate molecules.
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