RSPO BINDING AGENTS AND USES THEREOF

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United States of America Patent

SERIAL NO

15480081

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to RSPO-binding agents and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human RSPO proteins and modulate β-catenin activity. The present invention further provides methods of using agents that modulate the activity of RSPO proteins, such as antibodies that specifically bind RSPO1, RSPO2, and/or RSPO3 and inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.

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Patent Owner(s)

Patent OwnerAddress
ONCOMED PHARMACEUTICALS INC800 CHESAPEAKE DRIVE REDWOOD CITY CA 94063-4748

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
AXELROD, Fumiko Takada Palo Alto, US 24 353
CHARTIER-COURTAUD, Cecile Palo Alto, US 33 159
GURNEY, Austin L San Francisco, US 2150 10194
HOEY, Timothy Charles Hillsborough, US 36 469

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