ATTENUATED ZIKA VIRUS CONSTRUCTS AND USES THEREOF
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Mar 28, 2017
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Mar 28, 2016
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Novel attenuating deletions of Zika virus E2 polypeptides are provided as are attenuated viruses comprising the deletions. Also provided are immunogenic compositions that comprise the attenuated viruses and methods of producing such viruses in cells (such as insect cells). Viruses of the embodiments can be used for immunization of animals to provide protection from the pathogenic effects of Zika virus infection.
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