Method for Preparing Chitosan Matrices Having Improved Mechanical Properties
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United States of America Patent
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Sep 25, 2015
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Sep 26, 2014
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The present invention relates to a method for preparing a chitosan matrix having good mechanical properties comprising the steps of a) preparing a solution of chitosan, b) pouring the solution of a) into a mould in order to form a layer, c) lyophilizing the layer of b) in order to obtain a matrix of chitosan, d) sterilizing the matrix obtained in c) by water vapor treatment. The invention also relates to the matrices obtained and to surgical implants comprising such matrices. The invention further relates to a method for increasing the suture retention strength of a chitosan matrix obtained by lyophilization of a chitosan solution, and to a method for for decreasing the solubilization rate in hydrochloric acid of a chitosan matrix obtained by lyophilization of a chitosan solution, comprising the step of sterilizing said matrix by a water vapor treatment.
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