ORAL SPRAY CONTAINING IXERIS DENTATA NAKAI EXTRACT AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING XEROSTOMIA CAUSED BY DIABETES
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Feb 23, 2017
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Feb 23, 2016
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An oral spray formulation using an Ixeris dentata Nakai extract as an active ingredient of a composition for preventing and treating xerostomia occurring as a diabetic complication, particularly an oral spray formulation capable of administering a drug through a simple and rapidly absorbable route is provided. The secretion of saliva is reduced as cells from a submandibular gland tissue of a diabetes model animal are destroyed. However, when the Ixeris dentata Nakai extract of the present invention is sublingually sprayed into a sublingual region of the diabetes model animal, expression levels of α-amylase, AQP5 and NHE1 can significantly increase, resulting in an increased secretion quantity and rate of saliva.
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