Extraction of cfDNA from biological samples
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United States of America Patent
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Sep 22, 2020
Grant Date -
Oct 5, 2017
app pub date -
Mar 30, 2017
filing date -
Mar 30, 2016
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Abstract
Focused acoustic treatment of samples including a target biomolecule, such as cfDNA, may aid in the recovery of the biomolecule from a sample. cfDNA in a sample, whether chemically stabilized or not, may be linked or otherwise bound to histones or other proteins, e.g., by hydrogen bonds of histones or chaperone proteins to DNA and/or covalent crosslinks of such proteins to the DNA. Focused acoustic energy may remove or disrupt such links, aiding in isolation of the cfDNA from the sample.
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