Methods for improving proliferation and stemness of limbal stem cells
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United States of America Patent
Stats
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Jan 19, 2021
Grant Date -
Oct 5, 2017
app pub date -
Mar 20, 2017
filing date -
Mar 29, 2016
priority date (Note) -
In Force
status (Latency Note)
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Abstract
Provided are methods for improving the proliferation and stemness of limbal stem cells (LSCs) by adding a Wnt inhibitor to a medium for limbal explant cultures. When human limbal explants are cultured according to the methods, Wnt/β-catenin signaling is inhibited, resulting in improvement of LSC proliferation, and improvement in the stemness of LSCs, and thus the LSCs may be obtained in high yield.
First Claim
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| Country | kind | publication No. | Filing Date |
|---|---|---|---|
| KR | B1 | KR101789917 | Mar 29, 2016 |
International Classification(s)
- 2017 Application Filing Year
- C12N Class
- 8593 Applications Filed
- 4882 Patents Issued To-Date
- 56.82 % Issued To-Date
Cited Art Landscape
Patent Citation Ranking
- 0 Citation Count
- C12N Class
- 0 % this patent is cited more than
- 4 Age
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | Jul 19, 2028 |
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Jul 19, 2032 |
