Muscle-specific nucleic acid regulatory elements and methods and use thereof
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United States of America Patent
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Aug 4, 2020
Grant Date -
Sep 28, 2017
app pub date -
Mar 27, 2017
filing date -
Jan 21, 2014
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Abstract
The present invention relates to nucleic acid regulatory elements that are able to enhance muscle-specific expression of genes, in particular expression in cardiac muscle and/or skeletal muscle, methods employing these regulatory elements and uses of these elements. Expression cassettes and vectors containing these nucleic acid regulatory elements are also disclosed. The present invention is particularly useful for applications using gene therapy, more particularly muscle-directed gene therapy, and for vaccination purposes.
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