INDUCED PLURIPOTENT STEM CELLS
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United States of America Patent
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Issued Date -
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app pub date -
Jan 11, 2017
filing date -
Jul 22, 2010
priority date (Note) -
Abandoned
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Abstract
Described herein is a major breakthrough in nuclear reprogramming and induced pluripotent stem cell (iPSC) technology. Fusion of the powerful transcription activation domain (TAD) of MyoD to the Oct4 protein makes iPSCs generation faster, more efficient, purer, safer and feeder-free. Also, disclosed herein is the first report of the use of a TAD fused to a transcription factor as a method for making iPSCs. By combining transcription factors and TADs, this approach to nuclear reprogramming can have a range of applications from inducing pluriopotency to inducing transdifferentiation without transitioning through iPSCs.
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Family

- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
---|---|---|
REGENTS OF THE UNIVERSITY OF MINNESOTA | 600 MCNAMARA ALUMNI CENTER 200 OAK STREET SE MINNEAPOLIS MN 55455-2020 |
International Classification(s)
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Hirai, Hiroyuki | Ann Arbor, US | 151 | 5793 |
# of filed Patents : 151 Total Citations : 5793 | |||
Kikyo, Nobuaki | Edina, US | 3 | 3 |
# of filed Patents : 3 Total Citations : 3 |
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