INDUCED PLURIPOTENT STEM CELLS

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United States of America Patent

SERIAL NO

15403653

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Described herein is a major breakthrough in nuclear reprogramming and induced pluripotent stem cell (iPSC) technology. Fusion of the powerful transcription activation domain (TAD) of MyoD to the Oct4 protein makes iPSCs generation faster, more efficient, purer, safer and feeder-free. Also, disclosed herein is the first report of the use of a TAD fused to a transcription factor as a method for making iPSCs. By combining transcription factors and TADs, this approach to nuclear reprogramming can have a range of applications from inducing pluriopotency to inducing transdifferentiation without transitioning through iPSCs.

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Patent OwnerAddress
REGENTS OF THE UNIVERSITY OF MINNESOTA600 MCNAMARA ALUMNI CENTER 200 OAK STREET SE MINNEAPOLIS MN 55455-2020

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hirai, Hiroyuki Ann Arbor, US 151 5793
Kikyo, Nobuaki Edina, US 3 3

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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges2925224021854181131251101 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +0200400600800100012001400160018002000220024002600280030003200

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