MODEL SYSTEMS FOR SCREENING MODULATORS OF mTOR SIGNALING
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United States of America
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Sep 14, 2017
app pub date -
May 25, 2017
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May 25, 2017
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Abstract
The presently disclosed subject matter relates to the generation of induced pluripotent stem cell (iPSC)-derived neuronal cell lines from subjects diagnosed with polyhydramnios-megalencephaly-symptomatic-epilepsy (PMSE) and assays making use of such cell lines to identify mammalian target of rapamycin (mTOR) signalling modulators as well as anti-epileptogenic compounds.
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