Point mutations in TRK inhibitor-resistant cancer and methods relating to the same
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United States of America Patent
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Jul 28, 2020
Grant Date -
Sep 14, 2017
app pub date -
Oct 26, 2016
filing date -
Oct 26, 2015
priority date (Note) -
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Abstract
Provided herein are methods of treating a subject having a cancer, methods of selecting a treatment for a subject having a cancer, methods of selecting a subject having a cancer for a treatment that does not include a Trk inhibitor, methods of determining the likelihood that a subject having a cancer will have a positive response to a treatment with a Trk inhibitor, methods of predicting the efficacy of a Trk inhibitor in a subject having cancer, methods of determining a subject's risk for developing a Trk inhibitor-resistant cancer, and methods of determining the presence of a Trk inhibitor-resistant cancer in a subject, based on the detection of a cell from a sample from the subject that has at least one of the point mutations in NTRK1 and/or NTRK2 and/or NTRK3.
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