Lipid sterilization method
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United States of America Patent
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Jan 12, 2021
Grant Date -
Sep 14, 2017
app pub date -
Jun 26, 2015
filing date -
Jun 26, 2014
priority date (Note) -
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Abstract
The present invention relates to a method for sterilisation of phospholipid suspensions, useful in the preparation of ultrasound contrast agent precursors comprising phospholipid-stabilised perfluorobutane microbubbles. The method provides sterility assurance, without undue thermal degradation of the phospholipid. The method is also amenable to commercial scale manufacture. Also provided are methods of preparing kits and ultrasound contrast agents incorporating the sterilisation method of the invention.
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| 7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | Jul 12, 2028 |
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