METHOD FOR TREATING PROSTATE CANCER

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United States of America

APP PUB NO 20170258793A1
SERIAL NO

15470034

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Abstract

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The invention provides a method for treating prostate cancer in a subject comprising administering to the subject an effective amount of a selective inhibitor of one or more of CDK8 and CDK19. In some embodiments the inhibitor inhibits CDK19. In some embodiments, the inhibitor inhibits CDK8 at a Kd of lower than 200 nM and/or inhibits CDK19 at a Kd of lower than 100 nM. In some embodiments, the prostate cancer is androgen independent. In some embodiments, the prostate cancer is androgen independent due to one or more of androgen receptor gene amplification, androgen receptor gene mutation, ligand-independent transactivation of androgen receptor and activation of intracellular androgen synthesis. In some embodiments, the inhibitor inhibits increased activity of NF-κB. In some embodiments, the inhibitor does not inhibit increased basal levels of NF-κB.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF SOUTH CAROLINAOSBORNE ADMINISTRATION BUILDING STE 109 COLUMBIA SC 29208

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  • 2017 Application Filing Year
  • A61K Class
  • 21227 Applications Filed
  • 12841 Patents Issued To-Date
  • 60.50 % Issued To-Date
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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
CHEN, Mengquian Columbia, US 1 0
Roninson, Igor B Lexington, US 73 459

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