METHOD FOR TREATING PROSTATE CANCER
Number of patents in Portfolio can not be more than 2000
United States of America
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N/A
Issued Date -
Sep 14, 2017
app pub date -
Mar 27, 2017
filing date -
Mar 27, 2017
priority date (Note) -
Published
status (Latency Note)
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Abstract
The invention provides a method for treating prostate cancer in a subject comprising administering to the subject an effective amount of a selective inhibitor of one or more of CDK8 and CDK19. In some embodiments the inhibitor inhibits CDK19. In some embodiments, the inhibitor inhibits CDK8 at a Kd of lower than 200 nM and/or inhibits CDK19 at a Kd of lower than 100 nM. In some embodiments, the prostate cancer is androgen independent. In some embodiments, the prostate cancer is androgen independent due to one or more of androgen receptor gene amplification, androgen receptor gene mutation, ligand-independent transactivation of androgen receptor and activation of intracellular androgen synthesis. In some embodiments, the inhibitor inhibits increased activity of NF-κB. In some embodiments, the inhibitor does not inhibit increased basal levels of NF-κB.
First Claim
all claims..Other Claims data not available
Family
Country | kind | publication No. | Filing Date | Type | Sub-Type |
---|---|---|---|---|---|
JP | B2 | JP6310470 | Nov 01, 2013 | Patent | Grant |
Type : Patent Sub-Type : Grant | |||||
PUBLISHED GRANTED PATENT (SECOND LEVEL) | 前立腺がんを処置するための方法 | Apr 11, 2018 | |||
EP | B1 | EP2914266 | Nov 01, 2013 | Patent | Grant |
Type : Patent Sub-Type : Grant | |||||
Patent | CDK8/CDK19 SELECTIVE INHIBITORS FOR USE IN A METHOD FOR TREATING PROSTATE CANCER | Jun 19, 2019 | |||
US | B2 | US9636342 | Nov 01, 2013 | Patent | Grant |
Type : Patent Sub-Type : Grant | |||||
GRANTED PATENT AS SECOND PUBLICATION | Method for treating prostate cancer | May 02, 2017 | |||
KR | A | KR20160014568 | Nov 01, 2013 | Patent | Application |
Type : Patent Sub-Type : Application | |||||
UNEXAMINED PATENT APPLICATION | 전립선암을 치료하는 방법 | Feb 11, 2016 | |||
WO | A1 | WO2014071143 | Nov 01, 2013 | Patent | Application |
Type : Patent Sub-Type : Application | |||||
INTERNATIONAL APPLICATION PUBLISHED WITH INTERNATIONAL SEARCH REPORT | METHOD FOR TREATING PROSTATE CANCER | May 08, 2014 | |||
CA | C | CA2890108 | Nov 01, 2013 | Patent | Grant |
Type : Patent Sub-Type : Grant | |||||
PATENT (SECOND LEVEL) | METHOD FOR TREATING PROSTATE CANCER | Mar 02, 2021 |
- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
---|---|---|
UNIVERSITY OF SOUTH CAROLINA | OSBORNE ADMINISTRATION BUILDING STE 109 COLUMBIA SC 29208 |
International Classification(s)

- 2017 Application Filing Year
- A61K Class
- 21227 Applications Filed
- 12841 Patents Issued To-Date
- 60.50 % Issued To-Date
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
CHEN, Mengquian | Columbia, US | 1 | 0 |
# of filed Patents : 1 Total Citations : 0 | |||
Roninson, Igor B | Lexington, US | 73 | 459 |
# of filed Patents : 73 Total Citations : 459 |
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- 0 Citation Count
- A61K Class
- 0 % this patent is cited more than
- 8 Age
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7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | Mar 14, 2025 |
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