METHOD TO IMPROVE THE IDENTIFICATION, QUANTIFICATION AND SPATIAL LOCALIZATION OF MULTIPLY CHARGED MOLECULES IN BIOLOGICAL SAMPLES USING ION MOBILITY INFORMATION
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Feb 17, 2017
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Feb 18, 2016
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Described herein is a method of analyzing a sample including molecules having two or more possible sites for ionization comprising: 1) separating ionized molecules of the sample according to ion mobility of the ionized molecules, and 2) analyzing the ionized molecules using mass spectrometry. Additionally described herein is a method of diagnosing and/or determining the progression of a disease or disorder associated with gangliosides and/or cardiolipins in a subject comprising: 1) separating ionized molecules in a biological sample from the subject according to ion mobility of the ionized molecules, and 2) analyzing the ionized molecules using mass spectrometry to identify and quantify gangliosides and/or cardiolipins in the sample.
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