COMPOSITION USING GUANIDINE COMPOUND FOR SUPPRESSING TRANSFORMING GROWTH FACTOR (TGF)-beta

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United States of America Patent

APP PUB NO 20170246129A1
SERIAL NO

15054450

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Abstract

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The present invention relates to a composition as a transforming growth factor (TGF)-β suppressor which comprises an effective amount of guanidine compound or a pharmaceutically acceptable salt. More particularly, the present invention relates to a composition comprising a guanidine compound or a pharmaceutically acceptable salt thereof as a TGF-β suppressor, wherein the composition is characterized by suppression or reduction of TGF-β activity which is a cause of disease. The present invention relates to a method of treating various TGF-β associated diseases, the method comprising administering to the subject a composition comprising a guanidine compound or a pharmaceutically acceptable salt thereof as a TGF-β suppressor which can prevent or treat TGF-β associated diseases by suppressing or reducing TGF-β activity.

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Patent Owner(s)

Patent OwnerAddress
INSTITUTE OF CHEMISTRY CHINESE ACADEMY OF SCIENCES100190 NO 2 NORTH FIRST STREET HAIDIAN DISTRICT BEIJING ZHONGGUANCUN BEIJING CITY BEIJING CITY 100190
INSTITUTE OF HIGH ENERGY PHYSICS CHINESE ACADEMY OF SCIENCES100049 NO 19 (B) HOSPITAL SHIJINGSHAN DISTRICT YUQUANLU ROAD BEIJING BEIJING CITY BEIJING CITY 100049
PEKING UNIVERSITY THIRD HOSPITALHUA YUAN NORTH ROAD 49# HAIDIAN DISTRICT BEIJING 100191

International Classification(s)

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  • 2016 Application Filing Year
  • A61K Class
  • 19101 Applications Filed
  • 13019 Patents Issued To-Date
  • 68.16 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances20162017201820192020202120222023202420250255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
FANG, Xiaohong Beijing, CN 3 2
LI, Jingyuan Beijing, CN 14 18
LU, Zhizhen Beijing, CN 1 0
XIAO, Han Beijing, CN 53 194
XU, Zhonghe Beijing, CN 1 0
ZHANG, Mingliang Beijing, CN 17 89
ZHANG, Youyi Beijing, CN 3 8

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