Microbial approach for the production of 5-hydroxytryptophan

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United States of America Patent

PATENT NO 10023889
APP PUB NO 20170240939A1
SERIAL NO

15310040

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Abstract

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5-hydroxytryptophan (5-HTP), a precursor of serotonin, is produced in a microbial host cell. A modified bacterial phenylalanine 4-hydroxylase (P4H) catalyzes the tryptophan 5-hydroxylation reaction. Optionally the host cell includes a cofactor regeneration mechanism, allowing continuous production of 5-HTP without supplementation of exogenous cofactors.

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Patent Owner(s)

Patent OwnerAddress
GENEDARTEC INC1051 SUNSTONE DRIVE BOGART GA 30622

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lin, Yuheng Bogart, US 9 29
Yan, Yajun Bogart, US 15 64

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