METHODS FOR GENOMIC MODIFICATION
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United States of America Patent
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Issued Date -
Aug 24, 2017
app pub date -
Feb 3, 2017
filing date -
Apr 27, 2011
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Abstract
Provided herein are methods of integrating one or more exogenous nucleic acids into one or more selected target sites of a host cell genome. In certain embodiments, the methods comprise contacting the host cell genome with one or more integration polynucleotides comprising an exogenous nucleic acid to be integrated into a genomic target site, and a nuclease capable of causing a double-strand break near or within the genomic target site.
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