Method and means for purifying retroviral vectors
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United States of America Patent
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Aug 18, 2020
Grant Date -
Aug 24, 2017
app pub date -
Aug 28, 2015
filing date -
Aug 29, 2014
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Abstract
The present invention relates to a producer cell which expresses a tagging protein at the cell surface, such that retroviral vectors produced by the cell are tagged with the tagging protein, wherein the tagging protein comprises: i) a binding domain which binds to a capture moiety ii) a spacer; and iii) a membrane targeting domain such that, when incorporated a retroviral vector, the tagging protein facilitates purification of the retroviral vector from cellular supernatant via binding of the tagging protein to the capture moiety. The present invention also relates to a retroviral vector comprising such a producer cell-derived tagging protein.
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