Method for quantitative characterization of substances with regard to their properties of binding to amyloid-β (Aβ) conformers
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United States of America Patent
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Aug 18, 2020
Grant Date -
Aug 17, 2017
app pub date -
Jun 25, 2014
filing date -
Jul 12, 2013
priority date (Note) -
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Abstract
A method for the quantitative characterization of substances with regard to their properties of binding to amyloid-β (Aβ) conformers, comprising the steps of: —fractionating a sample including various Aβ conformers; —immobilizing a biotinylated Aβ conformer of the desired fraction on the surface of a substrate having high affinity for biotin; and —deriving the binding behavior of an aggregate quality control probe to the desired Aβ conformer from the measurement signal by determining the kinetic and/or thermodynamic parameters. A device for carrying out the method.
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International Classification(s)
- 2014 Application Filing Year
- G01N Class
- 10055 Applications Filed
- 7887 Patents Issued To-Date
- 78.44 % Issued To-Date
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- G01N Class
- 0 % this patent is cited more than
- 5 Age
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