MODULATORS OF VIRUS ASSEMBLY AS ANTIVIRAL AGENTS
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United States of America Patent
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Issued Date -
Aug 10, 2017
app pub date -
Oct 6, 2016
filing date -
Aug 2, 2011
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Abstract
In addition to containing and protecting the viral genome, the capsid (protein shell) of hepatitis B virus (HBV) plays critical roles in the viral life cycle including regulation of intracellular trafficking and nucleic acid metabolism. Substituted pyrimidine modulators of the assembly of the HBV capsid structure and methods for their use are described.
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