Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy

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United States of America Patent

PATENT NO 10888567
APP PUB NO 20170224701A1
SERIAL NO

15503210

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Abstract

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Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the Formula I having IDO1 and/or TDO inhibitory activity are described, where W is CR1, N or N-oxide; X is CR2, N or N-oxide; Y is CR3, N or N-oxide; Z is CR4, N or N-oxide; and at least one of W, X, Y, and Z is N or N-oxide; and R9 and R10 are as defined. Also described are methods of using such compounds in the treatment of various conditions, such as cancer.

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Patent Owner(s)

Patent OwnerAddress
AUCKLAND UNISERVICES LIMITEDAUCKLAND 1010

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ching, Lai Ming Auckland, NZ 5 7
Gamage, Swarnalatha Akuratiya Auckland, NZ 17 67
Palmer, Brian Desmond Auckland, NZ 17 86

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