USES OF SALT-INDUCIBLE KINASE (SIK) INHIBITORS

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United States of America Patent

SERIAL NO

15502287

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Abstract

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The present disclosure provides methods of treating and/or preventing inflammatory bowel disease (IBD) and graft-versus-host disease (GVHD) using salt-inducible kinase (SIK) inhibitors, such as macrocyclic SIK inhibitors of Formula (I), imidazolyl SIK inhibitors of Formula (II), and urea and carbamate SIK inhibitors of Formula (III-A) (e.g., urea and carbamate SIK inhibitors of Formula (III)).

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Patent Owner(s)

Patent OwnerAddress
THE BROAD INSTITUTE INC415 MAIN STREET CAMBRIDGE MA 02142

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Choi, Hwan Geun Chestnut Hill, US 69 786
Gray, Nathanael S Boston, US 247 2143
Liang, Yanke Brookline, US 54 471
Schreiber, Stuart L Boston, US 96 2320
Shamji, Alykhan Somerville, US 13 63
Sundberg, Thomas Boston, US 17 379
Xavier, Ramnik Brookline, US 29 77

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