METHODS AND COMPOSITIONS FOR SELECTIVE DETECTION OF HOMOSYSTEINE

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United States of America Patent

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15320392

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Abstract

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Compositions and methods have been developed for the detection of homocysteine. For example, a fluorescent probe can selectively detect homocysteine based on the redox reaction between the azido group and homocysteine. The fluorescent response is selective for homocysteine over other biologically abundant thiols such as cysteine and glutathione. In addition, a linear calibration curve can be obtained for quantitative analysis in phosphate buffer and plasma.

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Patent Owner(s)

Patent OwnerAddress
GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC58 EDGEWOOD AVENUE SE 3RD FLOOR ATLANTA GA 30302

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Peng, Hanjing Lutherville, US 9 12
Wang, Binghe Marietta, US 30 241
Wang, Ke Chamblee, US 411 3121

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