MORPHOLINO-MEDIATED INCREASE IN SOLUBLE FLT-1 EXPRESSION RESULTS IN DECREASED OCULAR AND TUMOR NEOVASCULARIZATION

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United States of America Patent

SERIAL NO

15364142

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Methods of inhibiting lymphangiogenesis and/or angiogenesis in a subject are provided. In one aspect, for example, a method of inhibiting angiogenesis in a subject can include binding an antisense morpholino to an mRNA splicing site of VEGFR1 selected from exon13_intron13 junction, intron13_exon14 junction, or a combination thereof. In another aspect, the morpholino includes a member selected from VEGFR1_MOe13, VEGFR1_MOi13, or a combination thereof.

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UNIVERSITY OF UTAH RESEARCH FOUNDATIONUTAH USA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
AMBATI, Balamurali K Sandy, US 23 166
UEHARA, Hironori Salt Lake City, US 8 19

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