Soluble bacterial and fungal proteins and methods and uses thereof in inhibiting and dispersing biofilm
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United States of America Patent
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Feb 2, 2021
Grant Date -
Aug 3, 2017
app pub date -
Jun 5, 2015
filing date -
Jun 6, 2014
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Abstract
The present disclosure relates to methods of treating or preventing a biofilm-related infection and methods of preventing and treating biofilm formation on indwelling medical devices, implants, and non-medical surfaces comprising administering at least one soluble microbial protein that is encoded by an exopolysaccharide biosynthetic operon or functional gene cluster, wherein the protein comprises a glycosyl hydrolase domain. The present disclosure further provides particular soluble glycosyl hydrolases and compositions thereof.
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