EFFICIENT INHIBITION OF HSP27

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United States of America Patent

SERIAL NO

15329693

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Abstract

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The present invention relates to novel HSP27 inhibitors, in particular purine derivatives according to general formula (I) or (II) and phenothiazine derivatives according to formula (V), and to their use as drugs for the selective inhibition of the heat shock protein HSP27 (HSPB1), in particular for use in the treatment of carcinomas or cystic fibrosis, said inhibitors having a particularly advantageous activity in the lower micromolar or sub-micromolar active ingredient concentration range with respect to HSP2.

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Patent Owner(s)

Patent OwnerAddress
TECHNISCHE UNIVERSITAET DRESDENHELMHOLZSTR 10 DRESDEN 01069

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Donakonda, Sainitin Hyderabad, Andhra Pradesh, IN 2 0
Haupt, Joachim Bobritzsch-Hilbersdorf, DE 9 37
Heinrich, Joerg-Christian Dresden, DE 4 1
Lennig, Petra Dresden, DE 16 111
Schroeder, Michael Dresden, DE 52 1460
Zhang, Yixin Dresden, DE 47 150

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