Methods for predicting response to DNA repair pathway inhibitors in diffuse large B-cell lymphoma

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United States of America Patent

PATENT NO 10676791
APP PUB NO 20170211151A1
SERIAL NO

15328918

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Abstract

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The present invention relates to a method of testing whether a patient suffering from arge B-cell lymphoma will respond or not to a DNA repair pathway inhibitor comprising: i) determining the expression level (ELi) of several genes Gi-Gn selected from table A in a biological sample obtained from said patient comparing the expression level (ELi) determined at step i) with a predetermined reference level (ELRi) iii) calculating the DNA repair score trough the following formula (I), wherein βi represent the regression β coefficient reference value for the gene Gi and Ci=1 if the expression of the gene Gi (ELi) is higher than the predetermined reference level (ELRi) or Ci=−1 if the expression of the gene (ELi) is lower than or equal to the predetermined reference level (ELRi) iv) comparing the score DNARS determined at step iii) with a predetermined reference value DNARSR v) and concluding that the patient will respond to the treatment when the DNARS score is higher than the predetermined reference value DNARSg or concluding that the patient will not respond to the treatment when the DNARS score is lower than the predetermined reference value DNARSR.

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Patent Owner(s)

Patent OwnerAddress
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)75700 PARIS CEDEX 07
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)PARIS FRANCE PARIS PARIS
UNIVERSITÉ DE MONTPELLIER34090 MONTPELLIER
CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER191 AVENUE DOYEN GASTON GIRAUD MONTPELLIER F-34000

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bret, Caroline Montpellier, FR 4 2
Cartron, Guillaume Montpellier, FR 12 76
Constantinou, Angelos Montpellier, FR 1 2
Moreaux, Jerome Montpellier, FR 4 2
Pasero, Philippe Montpellier, FR 1 2

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