Methods of treating TTP with immunoglobulin single variable domains and uses thereof
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United States of America Patent
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Dec 8, 2020
Grant Date -
Jul 27, 2017
app pub date -
Jun 16, 2015
filing date -
Jun 16, 2014
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Abstract
The present invention is based on the finding that administration of polypeptides comprising at least one Immunoglobulin single variable domains against vWF to human TTP patients provides a significant decrease in the time to response. The invention provides a polypeptide comprising at least one immunoglobulin single variable domain (ISVD) against von Willebrand Factor (vWF) for use in treating a vWF-related disease in a human in need thereof. The invention further relates to dosage unit forms, kits and medical uses for treating TTP.
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