Combination of broadly neutralizing HIV antibodies and viral inducers
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United States of America Patent
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Jun 9, 2020
Grant Date -
Jul 27, 2017
app pub date -
Jul 21, 2015
filing date -
Jul 21, 2014
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Abstract
The present invention relates to methods and agents for preventing the establishment of HIV-1 latent reservoirs or for reducing the size of the reservoirs. Specifically, the disclosure provides methods and agents for preventing the establishment of HIV-1 latent reservoirs or for reducing the size of the reservoirs, the methods comprising administering to the subject a therapeutically effective amount of an isolated anti-HIV antibody, and administering to the subject two or more viral transcription inducers in effective amounts to induce transcription of an HIV provirus in the cells. Further provided are antibodies and viral transcription inducers used in the methods.
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