Methods and compounds to suppress viral genome release and packaging
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United States of America Patent
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Jul 7, 2020
Grant Date -
Jul 27, 2017
app pub date -
Jan 30, 2017
filing date -
Jul 28, 2015
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Abstract
Provided herein are methods of suppressing viral nucleic acid, e.g. double-stranded (ds) DNA, genome release from or packaging of viruses having their nucleic acid genome packaged under stress in their capsid, and compositions useful for that purpose. The methods alter the ionic environment of the nucleic acid within the capsid and thereby prevent release of, and/or interfere with packaging of the viral genome.
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