Fluorescent AMP-kinase biosensors

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United States of America Patent

PATENT NO 10935546
APP PUB NO 20170205400A1
SERIAL NO

15319646

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Abstract

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The present invention deals with heterotrimeric AMP-activated protein kinase (AMPK) comprising a fluorophore pair wherein the conformational change can be measured by FRET. It represents an advanced tool to screen and identify AMPK interactors in vitro and in cells in vivo. Such invention can also be considered as a reporter of the cellular energy status as it allows the spatiotemporal monitoring, in situ, of fluctuations in the ratio of AMP and ADP versus ATP.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITE GRENOBLE ALPES621 AVENUE CENTRALE 38400 SAINT-MARTIN D'HERES 38400
EUROPEAN MOLECULAR BIOLOGY LABORATORYMEYERHOFSTRASSE 1 69117 HEIDELBERG GERMANY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Berger, Imre Saint Egrève, FR 12 20
Pelosse, Martin Grenoble, FR 1 1
Schlattner, Uwe Montbonnot, FR 1 1

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