METHOD FOR THE MANUFACTURING OF DI-CHAIN PROTEINS FOR USE IN HUMANS
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United States of America Patent
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app pub date -
Mar 20, 2017
filing date -
Dec 23, 2011
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Abstract
This invention relates to a novel method for producing di-chain proteins for use in humans from single-chain precursors, including di-chain clostridial neurotoxins. The method comprises the step of expressing a nucleic acid sequence encoding a single-chain precursor comprising a thrombin-cleavage site and the step of cleaving the single-chain precursor with a human factor Xa or a human thrombin, particularly a human thrombin drug product authorized for human therapeutic use. The invention further relates to novel di-chain clostridial neurotoxins and nucleic acid sequences encoding such novel di-chain clostridial neurotoxins.
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Family
| Country | kind | publication No. | Filing Date |
|---|---|---|---|
| WO | A1 | WO2013091895 | Dec 21, 2012 |
| US | A1 | US20140377248 | Dec 21, 2012 |
| EP | B1 | EP2793934 | Dec 21, 2012 |
| US | A1 | US20160068830 | Nov 18, 2015 |
International Classification(s)
- 2017 Application Filing Year
- C12N Class
- 8593 Applications Filed
- 4882 Patents Issued To-Date
- 56.82 % Issued To-Date
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- C12N Class
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- 8 Age