Multi-chain polypeptide-containing tri-specific binding molecules that specifically bind to multiple cancer antigens
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United States of America Patent
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Apr 28, 2020
Grant Date -
Jul 20, 2017
app pub date -
May 29, 2015
filing date -
May 29, 2014
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Abstract
The present invention relates to Tri-Specific Binding Molecules, which are multi-chain polypeptide molecules that possess three Binding Domains and are thus capable of mediating coordinated binding to three epitopes. The Tri-Specific Binding Molecule is preferably characterized in possessing binding domains that permit it to immunospecifically bind to: (1) an epitope of a first Cancer Antigen, (2) an epitope of a second Cancer Antigen, and (3) an epitope of a molecule that is expressed on the surface of an immune system effector cell, and are thus capable of localizing an immune system effector cell to a cell that expresses a Cancer Antigen, so as to thereby facilitate the killing of such cancer cell.
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