Methods for predicting response to treatment
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United States of America Patent
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Jan 19, 2021
Grant Date -
Jul 13, 2017
app pub date -
Jan 12, 2017
filing date -
Jan 12, 2016
priority date (Note) -
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Abstract
The present invention provides stratification methods and kits to identify whether an individual having an inflammation-related disorder has genotype-specific differential expression of IL-1, i.e., is a “high” or “low” producer of IL-1, such that s/he can be provided an appropriate anti-inflammatory drug and at an appropriate dose. The stratification of high or low IL-1 producers is used to guide assignment of different drug doses and therefore reduce drug toxicity and adverse events in an individual who, without stratification, may be prescribed a higher dose than needed to manage the primary indication. The use of IL-1 stratification of drug dosing would allow a better clinical benefit-risk appraisal in an individual patient.
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