4,5-diarylimidazole derivatives as HDAC inhibitors

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United States of America Patent

PATENT NO 9868750
SERIAL NO

15326381

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Abstract

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The present invention relates to a 4,5-diarylimidazole derivative of formulae (I), (II) or (III): or a pharmaceutically acceptable salt thereof, wherein the 4,5-diarylimidazole derivative has a hydroxamic acid residue at a first aryl ring and a residue R1 at a second aryl ring; and wherein R1 is hydrogen, a halogen atom or an unsubstituted or substituted alkoxy group; R2 is independently selected from an unsubstituted or substituted alkyl, alkoxy or alkene group; M is a metal atom; L is a halogen atom, an unsubstituted or substituted phosphane, sulfane, arene or alkene group or a 4,5-diarylimidazole-derivative of formula (I); and n is an integer of from 1 to 5.

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Patent Owner(s)

Patent OwnerAddress
CHARITE - UNIVERSITATSMEDIZIN BERLIN10117 BERLIN
UNIVERSITAT BAYREUTHUNIVERSITÄTSSTR 30 BAYREUTH 95440

International Classification(s)

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  • 2015 Application Filing Year
  • C07F Class
  • 1404 Applications Filed
  • 1070 Patents Issued To-Date
  • 76.22 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances2015201620172018201920202021202220230255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Biersack, Bernhard Prebitz, DE 2 8
Höpfner, Michael Berlin, DE 1 0
Mahal, Katharina Bayreuth, DE 1 0
Schobert, Rainer Bayreuth, DE 3 8

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  • C07F Class
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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges269279225101 - 1011 - 2021 - 3031 - 40020406080100120140160180200220240260280300

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