Unit dose of a cis-imidazoline for treating an osteoarthritic joint by removing senescent cells
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Dec 26, 2017
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app pub date -
Mar 10, 2017
filing date -
Jan 28, 2014
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Abstract
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
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