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Abstract

The invention discloses a new method of obtaining a pharmacologically active product that is a liposomal composition of phospholipid phosphatidylcholine and physiologically active substance—quercetin (3,3′, 4′, 5, 7-pentaoxyflavone). The substance of the invention to provide a method of optimized parameters sequential processes of dissolution, emulsification, dispersion and lyophilization that results in liposomal quercetin product with proven independent methods liposomal organisation, high stability and pharmacological activity. The high quality of the target product produced by the method claimed ensures the benefits of level and dynamics of integral pharmacological effect in non-clinical study, as compared with liposomal quercetin product produced by the the prototype method. The polytropic pharmacotherapeutic activity of the target product with demonstrated high level of harmlessness by different routes of administration, was to prove in the model of subtotal myocardial ischemia and reperfusion isolated heart performance in Guinea pigs by Langendorff method (the antiarrhythmic effect, normalisation of functional and hemodynamic characteristics of the myocardium), and also at the traumatic keratitis (reparative and anti-inflammatory effect). The invention is intended for use in pharmacy and medicine as a way to obtain a competitive product pharmacotherapy ophthalmologic and cardiologic diseases, adequate to different routes of administration.

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First Claim