Methods for detecting phosphorylated alpha-synuclein
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United States of America Patent
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Dec 1, 2020
Grant Date -
Jul 6, 2017
app pub date -
Aug 25, 2016
filing date -
Aug 25, 2015
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Abstract
The invention provides methods of detecting alpha-synuclein using a capture antibody and a reporter antibody. The capture antibody binds preferentially to full-length alpha-synuclein phosphorylated at residue 129 (PS129 alpha-synuclein) over unphosphorylated full-length alpha-synuclein. The 11A5 antibody is an example of a suitable capture antibody. The reporter antibody binds to an epitope within residues 40-55 of alpha-synuclein. The 23E8 antibody is an example of such an antibody. Because only a small proportion of alpha-synuclein is phosphorylated high sensitivity of detection below picomolar is advantageous.
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